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Publication

Modelling of PNP and OA Placebo Response: Working towards a unique model of the placebo response in chronic pain?

In analgesia randomized clinical trials (RCTs), the magnitude and the variability of the placebo response negatively impacts the…

Type: Scientific Poster
Authors: Samuel Branders, PhD ; Alvaro Pereira, PhD ; Erica Smith, PhD ; Dominique Demolle, PhD.
Conference: CNS Clinical Trials and Methodology (ISCTM)
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Publication

Identification Of Peripheral Neuropathic Pain Sensory Phenotypes Based On Specific Combinations Of Symptoms Identified With The NPSI (Neuropathic Pain Symptom Inventory)

One way to better personalized the treatment of peripheral neuropathic pain (PNP) would be to identify specific sensory…

Type: Scientific Presentation
Authors: Didier Bouhassira(1), Samuel Banders(2), Nadine Attal(1), Dominique Demolle(2) and Alvaro Pereira(2). 1- Inserm 987, Ambroise Pare Hospital, 92100 Boulogne-Billancourt, France 2- Tools4Patient, 50 rue de Bordeaux, boîte 17, 6040 Jumet, Belgium
Conference: European Pain Federation (EFIC)
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Publication

Leveraging Historical Data For High-dimensional Covariate-adaptive Randomization, A Machine Learning Approach.

There is a continuous growth in data collected in clinical trials. Many of those patient’s characteristics are potential…

Type: Scientific Presentation
Authors: Samuel Branders, PhD; Guillaume Bernard, PhD; Alvaro Pereira, PhD
Conference: Promoting Statistical Insight Conference
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Publication

Correcting For The Individual Patient Regression To The Mean Effect

Often, the primary endpoint of RCTs is defined as a change from baseline of a continuous outcome. In…

Type: Scientific Poster
Authors: Samuel Branders, PhD; Guillaume Bernard, PhD; Alvaro Pereira, PhD
Conference: American Society for Clinical Pharmacology and Therapeutics
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Publication

Putting Patient Uniqueness at the heart of Innovation

Access to innovative therapies remains an issue. In certain diseases, the magnitude and variability of individuals’ placebo response…

Type: Technology Presentation
Authors: Dominique Demolle, PhD; Stephanie Alvarez
Conference: Patient Partnering in Clinical Development Conference
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Publication

Leveraging historical data for high-dimensional regression adjustment, a machine learning approach.

The amount of data collected from patients involved in clinical trials is continuously growing. All those patient’s characteristics…

Type: Scientific Presentation
Authors: Samuel Branders, PhD; Guillaume Bernard, PhD; Alvaro Pereira, PhD
Conference: Promoting Statistical Insight Conference
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