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Tools4Patient Develops Predictive Model of the Placebo Response in Parkinson’s Disease

Tools4Patient presented data at the MDS Congress 2021 that predicted the placebo response in Parkinson’s disease (PD) in a multi-center, multi-national clinical study.

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Education

Clinical Trial Statistical Analysis: How to Minimize Noise

The main objective of most clinical trials is to evaluate efficacy and safety of an experimental treatment. To do this, statisticians compare the response of the drug-treated…

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Insights

The placebo response in drug development. Part 4: Irritable Bowel Disease

As in many other diseases (e.g. pain, osteoarthritis, rheumatoid arthritis, Parkinson’s Disease, etc ), patients participating in clinical trials for IBD treatments may experience a pronounced placebo…

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Multimedia

Predict placebo response using patient psychology to increase trial power

Advanced methods like AI and machine learning are uniquely poised to help scientists uncover the full spectrum of patient placebo responsiveness in a clinical trial. Learn more about this approach by attending our webinar, which explains how a solution like Placebell©™ leverages a time-tested predictive…

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Education

How to Increase Clinical Study Power with Covariate Adjustment

Adjustment for covariates helps clinical trial statisticians demonstrate differences in drug effect between groups of people. In this blog, we discuss what this means and how it…

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Insights

Minimizing Evaluation Error in Osteoarthritis Pain

Osteoarthritis trials have relatively a rate of failure due to many factors, including disease heterogeneity, a disconnect between pain improvement and structural improvement, a strong placebo response,…

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Multimedia

Predicting the placebo response in OA to improve the precision of the treatment effect estimation

The current abstract is the result of a collaboration between Unity biotechnology and Tools4 patient As you know, the placebo response is one of the major sources of variability in randomized clinical trials As a result, many trials fail due to a high placebo response. Unfortunately, this is also true in OA studies. However, within Tools4Patient, we have developed…

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