News | Events | Publications

The Placebo Response: A Hidden Risk to COVID-19 Trials” – First Opinion written by Tools4Patient authors published in STAT News

October 20, 2020

STAT News published “The Placebo Response: A Hidden Risk to COVID-19 Trials” written by Tools4Patient authors on October 13, 2020. The

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Tools4Patient expands into new office space

September 24, 2020

The Tools4Patient team has moved our offices to a new building located in the same scientific campus in Louvain-La-Neuve, Belgium in early September, 2020. The rapid expansion of collaborations with innovative biopharma companies has led to 30% growth of our team – particularly in scientific and operational support areas – over the last year.

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Decentralized Clinical Trials

With the potential to  improve recruitment rates, simplify compliance, reduce drop-out rates, and speed-up your product’s time to market, decentralized clinical trials represent an opportunity to rethink and refresh how research studies are

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Biotech Showcase – Digital Conference

The investor conference that drives the future of drug development. Event Date: January 11 – January 15, 2021Event Location: Delivered Digitally – US Pacific Standard TimeEvent Link: https://informaconnect.com/biotech-showcase/

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Bio Partnering at JPM

BIO One-on-One Partnering is a virtual partnering and business development companion, with integrated video conferencing. Event Date: January 11 – January 15, 2021Event Location: Delivered Digitally – US Pacific Standard TimeEvent

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“Stratification of patients based on the neuropathic pain symptom inventory (NPSI): development and validation of a new algorithm” published in Pain.

November 18, 2020

The journal article “Stratification of patients based on the neuropathic pain symptom inventory (NPSI): development and validation of a new algorithm”, has been published ahead of print in the journal Pain. This article was authored by Didier Bouhassira, MD, Director of Research at the National Institute for Health and Medical Research (INSERM) in France and member of Tools4Patient’s scientific advisory board, and was co-authored by Tools4Patient scientists Samuel Branders PhD, Alvaro Pereira PhD and Dominique Demolle, PhD.

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From covariates to confounding factors: the danger of having too many covariates

October 20, 2020

Clinical trials typically evaluate efficacy of experimental therapies in heterogeneous patient populations, as patient characteristics

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Regulatory Guidelines for the Use of Baseline Covariates to Increase Clinical Trial Study Power

October 15, 2020

Clinical trials data analyses can employ baseline covariates to control for factors that may impact

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Does the placebo response need to be considered in clinical trials for COVID-19 vaccines and treatments?

September 22, 2020

The search for drugs to treat and prevent SARS-CoV-2 infection is ongoing, with more than 1200 drugs in the pipeline and more 3,200 clinical trials planned or initiated as of 21 September 2020 (GlobalData). The success of these studies, however, may be at risk due to an invisible threat – the placebo response.

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Modelling of PNP and OA Placebo Response: Working towards a unique model of the placebo response in chronic pain?

In analgesia randomized clinical trials (RCTs), the magnitude and the variability of the placebo response negatively impacts the ability to demonstrate superiority of active compounds compared to placebo. The first objective of this analysis was to investigate parameters influencing the placebo response in PNP as a way to control for this major confounding factor.

Type: Scientific Poster

Authors: Samuel Branders, PhD ; Alvaro Pereira, PhD ; Erica Smith, PhD ; Dominique Demolle, PhD.

Date: February 2020

Conference: CNS Clinical Trials and Methodology (ISCTM)

Identification Of Peripheral Neuropathic Pain Sensory Phenotypes Based On Specific Combinations Of Symptoms Identified With The NPSI (Neuropathic Pain Symptom Inventory)

One way to better personalized the treatment of peripheral neuropathic pain (PNP) would be to identify specific sensory phenotypes of patients responding to different classes of drugs.

Type: Scientific Presentation

Authors: Didier Bouhassira(1), Samuel Banders(2), Nadine Attal(1), Dominique Demolle(2) and Alvaro Pereira(2). 1- Inserm 987, Ambroise Pare Hospital, 92100 Boulogne-Billancourt, France 2- Tools4Patient, 50 rue de Bordeaux, boîte 17, 6040 Jumet, Belgium

Date: September 2019

Conference: European Pain Federation (EFIC)

Leveraging Historical Data For High-dimensional Covariate-adaptive Randomization, A Machine Learning Approach.

There is a continuous growth in data collected in clinical trials. Many of those patient’s characteristics are potential confounding factors. Ideally, these factors should be accounted for in the randomization process to balance study arms and reduce the variability of the estimated treatment effect.

Type: Scientific Presentation

Authors: Samuel Branders, PhD; Guillaume Bernard, PhD; Alvaro Pereira, PhD

Date: June 2019

Conference: Promoting Statistical Insight Conference

Learn the importance of considering patient psychological traits, expectations, perception of patient relationship with the trial physician and staff, and social structure in efforts to understand the impact of the COVID-19 pandemic on clinical trials.

Date: June 2020

Erica Smith, VP of Business Development, speaks with Daniel Levin of The Bio Report Podcast about the Placebell©™ method to reduce the impact of the placeb response in drug development”.

Date: June 2019

Learn about how Tools4Patient considers the placebo response of each individual patient in clinical trials as a central part of the Placebell© methodology.

Date: March 2019

Erica Smith, VP of Business Development, discusses the benefits of the Placebell©™ approach in video interview at Biotech Showcase in San Francisco, CA.
Date: January, 2019

Date: January 2019

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