Identification Of Peripheral Neuropathic Pain Sensory Phenotypes Based On Specific Combinations Of Symptoms Identified With The NPSI (Neuropathic Pain Symptom Inventory)

Scientific Presentation made on September 2019 at the European Pain Federation (EFIC), Valencia, Spain. One way to better personalized the treatment of peripheral neuropathic pain (PNP) would be to identify specific sensory phenotypes of patients responding to different classes of drugs. Recent results have suggested that quantitative sensory testing (QST) could be useful, but these

Correcting For The Individual Patient Regression To The Mean Effect

Often, the primary endpoint of RCTs is defined as a change from baseline of a continuous outcome. In
such cases, regulators recommend including the outcome’s baseline value as a covariate in the
statistical analysis. Regression to the mean can explain the benefits of this procedure.

Putting Patient Uniqueness at the heart of Innovation

Technology Presentation made on March 2019 at the Patient Partnering in Clinical Development Conference, Berlin, Germany. Access to innovative therapies remains an issue. In certain diseases, the magnitude and variability of individuals’ placebo response (IPR) can confound detection of positive results in clinical trials. Despite the best efforts and investments by  pharmaceutical industry stakeholders, patients are

Leveraging historical data for high-dimensional regression adjustment, a machine learning approach.

Scientific Presentation made on June 2018 at the Promoting Statistical Insight Conference, London, United-Kingdom. The amount of data collected from patients involved in clinical trials is continuously growing. All those patient’s characteristics are potential covariates that could be used to improve study analysis and power. At the same time, the development of computerized systems simplifies