Tools4Patient Blog

Pandemic Stress Will Affect Clinical Trial Response: What Can Industry Do?

July 29, 2020

As one might expect, the life changes are a source of stress, and the data supports this assertion. In fact, a recent analysis by Express Scripts also showed an increase in prescriptions for medications to treat anxiety, depression and insomnia as a result of the pandemic.

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The Placebo response in drug development Part 3: Parkinson’s disease

July 16, 2020

Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and non-motor features. The disease has a significant clinical impact on patients, families, and caregivers through its progressive degenerative effects on mobility and muscle control.

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The placebo response in drug development. Part 2: Osteoarthritis

June 18, 2020

Osteoarthritis (OA) is common musculoskeletal disease with increased incidence and prevalence associated with aging. It affects around 10 % of the population and is 10 times more common than rheumatoid arthritis (RA).

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Are clinical trials patients’ reactions to crisis related to their personality? Application to the COVID-19 pandemic.

May 1, 2020

Not only are patient visits to clinical sites more difficult (or impossible), patients are also dealing with uncertainty, stress and anxiety. While keeping ongoing trials running is a top objective for many, understanding how this myriad of factors will affect trial data is paramount.

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Data Integrity in GCP environment

April 6, 2020

As clinical trials become more complex, are conducted at more sites with multiple vendors (clinical sites, CROs, e-PRO, data management vendors, etc.), properly protecting data integrity becomes increasingly critical.

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The Placebo response in drug development. Part 1: Rheumatoid Arthritis

March 5, 2020

Evidence has accumulated in recent years that the placebo response is a significant issue in evaluating efficacy of drugs for rheumatoid arthritis (RA). RA is a chronic disease characterized by inflammatory synovitis and progressive joint destruction.

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The Opioid Crisis in the US: Fueling the Next Wave of Drug Development for Chronic Pain

February 18, 2020

While the opioid crisis may be creating opportunity for development of novel therapies to treat chronic pain, drug development in this area has historically struggled. According to a BIO report released in 2018, only two novel NCEs were approved for pain indications from 2007-2017 while other analgesia approvals during this period were reformulations of existing compounds or drugs with approval history prior to 2007.

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Tools4Patient: Starting a new year with 20/20 hindsight

January 29, 2020

As 2019 came to a close and we begin a new decade, it’s an excellent opportunity to evaluate and learn from the past year and set a course for the future. Tools4Patient (T4P) had a momentous year as we increased on our focus on the commercialization of Placebell©™ – T4P’s innovative approach to reduce the impact of the

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Characterizing Personality Traits Related to the Placebo Response Using the MPsQ Questionnaire

November 19, 2019

Learn more about the development of the MPsQ and the its use as part of the Placebell©™ technology.

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Is the placebo effect contagious between investigators and patients?

November 12, 2019

A recent study published in Nature Human Behavior developed a methodology to understand and assess the role of physician expectation on the placebo response. Read more about this study here.

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